There have been many movies, TV shows, books, graphic novels, etc, featuring against-the-odds couples (eg. Romeo & Juliet) or enemies-turned-lovers (eg. Buffy & Spike). But they are nearly always hetero couples.
The only LGBT true couple I can think of who match this description are Sterling & April in Teenage Bounty Hunters (and, even then, they were hardly the worst of enemies). Otherwise, I only know of "almost" pairings: Cody (cis man) & Poison (trans woman) from Final Fight and Street Fighter definitely have chemistry. Albert (cis boy) & Peppo (trans girl) in Gankutsuou would have been perfect had they become a couple (they gave us some great moments!).
Are there any exciting against-the-odds couples or enemies-turned-lovers stories featuring LGBT characters? #lifestyle