which substance creates the greatest addiction related…
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which substance creates the greatest addiction related neuroadaptations after repeated exposure?
Ethonal, nicotine delta-9-tetrahydrocannabinol (THC),
a-PVP ?? What is it ?
I'm looking for comparative evidence, e.g., magnitude
and duration of mesolimbic dopamine signalling,
peak extracellular dopamine levels in the nucleus
accumbens, changes in D2/D3 receptor availability, and
density dopamine transporter (DAT) expression and
Function, incentive sensitization, synaptic plasticity within the mesolimbic reward pathway, and long-term structural or molecular adaptations, etc..
rather than subjective rankings or anecdotal reports. Are
there comparative studies that quantify these effects across different substances ?
Also, which measurable category would you say is the
most important here?
#animals
Ethonal, nicotine delta-9-tetrahydrocannabinol (THC),
a-PVP ?? What is it ?
I'm looking for comparative evidence, e.g., magnitude
and duration of mesolimbic dopamine signalling,
peak extracellular dopamine levels in the nucleus
accumbens, changes in D2/D3 receptor availability, and
density dopamine transporter (DAT) expression and
Function, incentive sensitization, synaptic plasticity within the mesolimbic reward pathway, and long-term structural or molecular adaptations, etc..
rather than subjective rankings or anecdotal reports. Are
there comparative studies that quantify these effects across different substances ?
Also, which measurable category would you say is the
most important here?
#animals
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