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How do calluses work? If your cells have DNA that…

How do calluses work?

If your cells have DNA that basically act as blueprints for every part and aspect of you, how do things like calluses work?

If there’s DNA that makes my hands soft and smooth, but I start doing some kind of hands-on work and develop calluses, does the DNA regarding my palms change? If so, is there a name for this “micro adaptation” thing? If not, how does it actually work?
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