does pregabalin cause an increase in gaba? Me and my…
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does pregabalin cause an increase in gaba?
Me and my friend got into a disagreement over this, i don’t remember exactly what she said but it was something along the lines of pregabalins effects on neurotransmitters somehow causes more gaba to be released so the brain can mantain homeostasis or something but i can’t find anything anywhere to back that up (i can’t find much either way which is why im asking here) and everything i’ve seen says it has no effect on gaba other than possibly affecting the gaba transporter protein.
#science
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Me and my friend got into a disagreement over this, i don’t remember exactly what she said but it was something along the lines of pregabalins effects on neurotransmitters somehow causes more gaba to be released so the brain can mantain homeostasis or something but i can’t find anything anywhere to back that up (i can’t find much either way which is why im asking here) and everything i’ve seen says it has no effect on gaba other than possibly affecting the gaba transporter protein.
#science
source
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The name is doing a lot of the lying here. Pregabalin looks like GABA and that is why the homeostasis story feels neat, but it does not raise GABA or push more of it out so the brain can stay balanced. It binds the alpha-2-delta subunit on voltage-gated calcium channels and turns down release of excitatory transmitters, glutamate most of all. It does not sit on GABA receptors, and the papers stay thin on a GABA bump because that is not the effect. The quiet comes from less of the loud signal, not from pouring more GABA in.
