A 3-Year-Old's Cancer Disappeared After Doctors…
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A 3-Year-Old's Cancer Disappeared After Doctors Reprogrammed His Own Immune Cells
When the boy was first diagnosed, he had a mass in the left lobe of his liver that measured 11.2 cm by 9.6 cm by 7.1 cm (4.4 × 3.8 × 2.8 inches).
The cancer had metastasized to his lungs, with indications that it had also spread to his bones.
The boy received three bouts of chemotherapy and had his primary liver tumor surgically removed, along with two operations to remove the cancer that had spread to his lungs.
Despite the interventions, the cancer rapidly returned, with a new tumor appearing in his lungs.
The treatment has shown huge promise in helping patients treat cancer, although its effectiveness has mostly been limited to treating blood cancers, not solid tumors.
But an inspirational real-life success story involving a three-year-old patient shows scientists are making big progress with CAR T cell therapy against solid tumors too – and with potentially life-saving results.
In a report published in *The New England Journal of Medicine* https://doi.org/10.1056/NEJMc2605958 , researchers document a case of complete regression of hepatoblastoma, a form of malignant liver cancer, in a 3-year-old boy, after CAR T cell treatment.
**After 12 months, the boy was still disease-free** – an incredible result and turnaround for the patient and his family, given the severity of his illness before his participation in the trial.
**Of course, it's worth pointing out that this is just a single report of one patient in an early-phase trial, and we'll need to see how other patients respond to the GPC3-CAR treatment before researchers know how effective and safe it is**.
#news #inspiration
When the boy was first diagnosed, he had a mass in the left lobe of his liver that measured 11.2 cm by 9.6 cm by 7.1 cm (4.4 × 3.8 × 2.8 inches).
The cancer had metastasized to his lungs, with indications that it had also spread to his bones.
The boy received three bouts of chemotherapy and had his primary liver tumor surgically removed, along with two operations to remove the cancer that had spread to his lungs.
Despite the interventions, the cancer rapidly returned, with a new tumor appearing in his lungs.
The treatment has shown huge promise in helping patients treat cancer, although its effectiveness has mostly been limited to treating blood cancers, not solid tumors.
But an inspirational real-life success story involving a three-year-old patient shows scientists are making big progress with CAR T cell therapy against solid tumors too – and with potentially life-saving results.
In a report published in *The New England Journal of Medicine* https://doi.org/10.1056/NEJMc2605958 , researchers document a case of complete regression of hepatoblastoma, a form of malignant liver cancer, in a 3-year-old boy, after CAR T cell treatment.
**After 12 months, the boy was still disease-free** – an incredible result and turnaround for the patient and his family, given the severity of his illness before his participation in the trial.
**Of course, it's worth pointing out that this is just a single report of one patient in an early-phase trial, and we'll need to see how other patients respond to the GPC3-CAR treatment before researchers know how effective and safe it is**.
#news #inspiration
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