YSK: Depression isn't just about serotonin
Why YSK: Understanding that there's more to depression can help to battle it or even stay ahead of it.
Experience - As someone who's battled it on and off for 14 years and taken over 30 medications to help...I've learned there are multiple neurotransmitter systems involved.
Norepinephrine and dopamine are also involved. For me serotonin wasn't the primary issue, the other two were. Understanding this and utilizing a search mechanism I'll list below can better help you understand what works well for you and what doesn't.
When looking into medications and what they do, always use the term "mechanism of action".
For example, Google - What is the mechanism of action for Zoloft? Then see what receptors it works on and adjust. You can do this for any medication.
**That being said the BEST anti-depressant I've ever taken is Cold Water Immersion in the morning.**
It boost dopamine \~200% for 1-5 hours after and it only takes up to 3 minutes of immersion in 55 degrees Fahrenheit or lower. It also boosts norepinephrine (brain adrenaline). I thought this was horse shit but I've been doing it and holy shit am I 10 years younger. I'm motivated, I'm a better husband, dad, worker, hobby enjoyer, life enjoyer...
Other things I've found that worked, focus on healthy sleep habits, VitD, Omega3s (2g a day for me), and getting sunlight asap in morning via a walk with my dog. Literally only walk a mile but sunlight boosts cortisol which gets you energized and moving!
I have been doing so many things for so many years...I hope this helps someone!