The battle began with two charges by the French heavy cavalry against the centre of the Spanish army, but these were both repulsed by intense Spanish artillery and arquebus fire. The next assault tried to force the Spanish right flank, but many of the French cavalrymen fell into the Spanish ditch and the attack was again thrown back by a storm of fire from the Spanish arquebusiers. One of those killed by the arquebus volleys was Nemours, making him possibly the first European general killed in action by small-arms fire.^(\)[*^(citation needed)* https://en.wikipedia.org/wiki/Wikipedia:Citation_needed^(\ ])
With the Swiss commander, Chandieu, taking charge, the Swiss pikemen attacked with the cavalry instead of waiting for the arrival of the French rearguard https://en.wikipedia.org/wiki/Rearguard and artillery under Yves d'Alègre. Seeing the imminent French infantry assault upon his center, Córdoba withdrew the arquebusiers to the flanks and the Landsknecht pikemen under von Ravenstein took their place behind the ditch. The Swiss formations, joined by the Gascon infantry, were unable to break into the defensive positions. Held by the Landsknechts in the front, fired into their flanks by the arquebusiers and harassed by the Spanish light cavalry, the Swiss and French were again driven back with heavy casualties, including Chandieu.