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Depressed individuals in a eight‐week treatment with selective serotonin reuptake inhibitors reduced the activity of 5-HT4 receptors | This finding is consistent with the expectation that the treatment increases the concentration of the neurotransmitter serotonin in the brain.
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How SSRIs affect serotonin receptors: New findings from a depression study

SSRIs reduced 5-HT4 receptor activity in the brain's neostriatum, supporting increased serotonin. Interestingly, smaller reductions in receptor activity were linked to better verbal memory improvements, although initial activity didn't predict treatment r...

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