Hyperexcitability drives calcium overload and

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Hyperexcitability drives calcium overload and excitotoxic motor neuron degeneration in amyotrophic lateral sclerosis . Calcium overload floods the endoplasmic reticulum and mitochondria, accelerating neuronal loss.
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The Calcium Connection: Explaining Motor Neuron Vulnerability in ALS | MDPI

HighlightsWhat are the main findings?Calcium dysregulation plays a key role in ALS, acting on the cellular, synaptic, and network levels to drive disease progression.Calcium dysregulation is linked to metabolic dysfunction, ER stress, and aberrant neuron-...

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Hyperexcitability drives calcium overload and excitotoxic…

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