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Does MSG really negatively affect some people?

This came up in a thread about debunked myths that persist to this day.

To my understanding, the stigma against monosodium glutamate arose from a letter, possibly intended as a joke, published by Science magazine in the sixties, which claimed that Chinese food was a cause of migraines. The idea went viral and the nocebo effect did the rest.

To this day, despite being present in much of the food we consume, many people will swear blind that MSG causes them a variety of symptoms, such as rapid heart rate and sweating.

Is there any truth to the myth?
#science
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